Acute Reduction of Glomerular Filtration and Renal Plasma Flow by Telazol in Laboratory Swine
The goal of this retrospective study was to determine whether having added tiletamine–zolazepam to an anesthetic cocktail of ketamine and xylazine (KX) during an ongoing series of studies of renal function in domestic pigs changed baseline renal hemodynamics. Group A (10 pigs) had been anesthetized with KX, group B (25 pigs) was anesthetized with tiletamine–zolazepam combined with KX (TKX), and group C (10 pigs) was anesthetized with KX. Measurements of baseline glomerular filtration rate (GFR; inulin clearance), effective renal plasma flow (eRPF; para-aminohippuric acid clearance), and mean blood pressure (BP) were made during three 15-min urine collection periods. GFR and eRPF were lower in group B (TKX) than in groups A and C (KX only) by 34% to 40% and 39% to 49%, respectively. BP did not differ between the 3 groups. GFR and eRPF in groups A and C were not different from each other. These findings suggest that adding tiletamine–zolazepam to an anesthetic cocktail can cause an acute decline in GFR and eRPF independent of arterial BP in laboratory swine.
Mean BP measured in group A (n = 10), group B (n = 25), and group C (n = 10). Each circle represents the average BP measured during the clearance period in one pig. The error bars adjacent to the circles indicate the mean and 1 SEM for that group.
GFR measured in group A (n = 10), group B (n = 25), and group C (n = 10). Each circle represents the average GFR during the clearance period in one pig. The error bars adjacent to the circles indicate the mean and 1 SEM for that group. +, P = 0.0035 comparing group A to group B; X, P = 0.0002 comparing group B to group C.
eRPF measured in group A (n = 10), group B (n = 25), and group C (n = 10). Each circle represents the average eRPF during the clearance period in one pig. The error bars adjacent to the circles indicate the mean and 1 SEM for that group. †, P = 0.0076 comparing group A to group B; §, P < 0.0001 comparing group B to group C.
Contributor Notes